低線量被曝 と ガン発症の因果関係が立証された!




25/05/2011 03:07:00 Health Canal.com

Helmholtz Zentrum Munchen(HZM)研究センターの科学者たちは、電離放射線被曝したことを示す甲状腺癌の遺伝子変化を発見した。遺伝子マーカー、いわゆる「放射線被曝指紋」はチェルノブイリ被災者の甲状腺乳頭癌患者において確認されたが、放射線被曝歴のない患者の甲状腺癌にはみられなかった。PNAS(米国科学アカデミー会報)の最新号でこの結果が公表された。




教授らのグループは、「EpiRadBio」(疫学的放射線生物学)プロジェクトでEURATOM(ユーラトム 欧州原子力共同体)が資金提供する将来の研究において、遺伝子指紋が甲状腺癌を引き起こすために必要とされる放射線被曝量を表示できるかどうかを見極めるために研究を拡大する予定である。


ジュリア・ヘス他  若年患者の甲状腺乳頭癌の染色体バンド7q11の増加は低線量放射線被爆と関連がある。米国科学アカデミー会報(PNAS);出版物へのリンク






Fingerprint of radiation exposure discovered in thyroid cancer
25/05/2011 03:07:00 Health Canal.com

Neuherberg,- Scientists from the Helmholtz Zentrum München have discovered a genetic change in thyroid cancer that points to a previous exposure of the thyroid to ionising radiation. The gene marker, a so-called „radiation fingerprint“ was identified in papilliary thyroid cancer cases from Chernobyl victims, but was absent from the thyroid cancers in patients with no history of radiation exposure. The results are published in the current issue of PNAS.

The research team, led by Prof. Horst Zitzelsberger and Dr. Kristian Unger from the Radiation Cytogenetics Unit of the Helmholtz Zentrums München, in collaboration with Prof. Geraldine Thomas, Imperial College London, studied thyroid cancers from children exposed to the radioiodine fallout from the Chernobyl nuclear reactor explosion. The team compared the genetic information from these tumours to that found in the same type of tumour that arose in children born more than one year after the explosion, after the radioactive iodine had decayed away. The number of copies of a small fragment of chromosome 7 was found to be increased only in the tumours from the irradiated children, establishing this as one of the first genetic markers that indicate a radiation aetiology of cancer.

This breakthrough is the first time since the reactor accident in 1986 that scientists have been able to discriminate between the cancers caused by the radioactive contamination and those that arise naturally. Prof. Zitzelsberger ascribes the success of this study to the careful collection, documentation and storage of thyroid cancers from the Chernobyl region in the Chernobyl Tissue Bank. He noted that this unique collection of materials made it possible for the team to compare for the first time tumours from children of the same age and regional background. The availability of the genetic marker, according to Prof. Zitzelsberger, will improve both the clinical diagnosis of thyroid cancer and our understanding of how radioactive iodine causes the disease to develop. In future studies funded by EURATOM in the project „EpiRadBio“ the group will extend the study to determine if the genetic fingerprint is able to indicate the level of radiation exposure that is required to cause the cancer.

Additional Information
Original Publication:

Hess, J. et al Gain of chromosome band 7q11 in papillary thyroid carcinomas of young patients is associated with exposure to low-dose irradiation. Proceeding of the National Academy of Sciences USA (PNAS); Link to publication


picture In papillary thyroid carcinomas, more copies of the CLIP2 gene (red) are detected than of a reference gene (green)

About Helmholtz Zentrum München

The Helmholtz Zentrum München is the German Research Centre for Environmental Health. The leading research facility in this field, it conducts research into chronic and complex diseases caused by the interaction of environmental factors and an individual’s genetic disposition. The Helmholtz Zentrum München has about 1,700 staff members and is headquartered in Neuherberg in the north of Munich on a 50-hectare research campus. The Helmholtz Zentrum München is a member of the Helmholtz Association, Germany’s largest scientific organization, a community of 17 scientific-technical and medical-biological research centers with a total of 30,000 staff members.


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